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Order-preserving principles underlying genotype-phenotype maps ensure high additive proportions of genetic variance.
- Source :
- Journal of Evolutionary Biology; Oct2011, Vol. 24 Issue 10, p2269-2279, 11p, 1 Chart, 4 Graphs
- Publication Year :
- 2011
-
Abstract
- In quantitative genetics, the degree of resemblance between parents and offspring is described in terms of the additive variance ( V<subscript>A</subscript>) relative to genetic ( V<subscript>G</subscript>) and phenotypic ( V<subscript>P</subscript>) variance. For populations with extreme allele frequencies, high V<subscript>A</subscript>/ V<subscript>G</subscript> can be explained without considering properties of the genotype-phenotype (GP) map. We show that randomly generated GP maps in populations with intermediate allele frequencies generate far lower V<subscript>A</subscript>/ V<subscript>G</subscript> values than empirically observed. The main reason is that order-breaking behaviour is ubiquitous in random GP maps. Rearrangement of genotypic values to introduce order-preservation for one or more loci causes a dramatic increase in V<subscript>A</subscript>/ V<subscript>G</subscript>. This suggests the existence of order-preserving design principles in the regulatory machinery underlying GP maps. We illustrate this feature by showing how the ubiquitously observed monotonicity of dose-response relationships gives much higher V<subscript>A</subscript>/ V<subscript>G</subscript> values than a unimodal dose-response relationship in simple gene network models. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1010061X
- Volume :
- 24
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Evolutionary Biology
- Publication Type :
- Academic Journal
- Accession number :
- 65328325
- Full Text :
- https://doi.org/10.1111/j.1420-9101.2011.02358.x