Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling!

Authors :: Simon Paine
James Lowe
Lynn Bedford
R. John Mayer
Source :: Biochemical Society Transactions; Aug2011, Vol. 39 Issue 4, p917-919, 3p
Publication Year :: 2011
Abstract: Chronic neurodegenerative disease is characterized by extensive regional loss of neurons in the brain and neuropathological hallmarks in surviving neurones. Genetic modelling by overexpression of hallmark proteins does not produce extensive neurodegeneration, whereas genetic deletion of neuronal 26S proteasomes does, as well as some hallmarks of human disease. [ABSTRACT FROM AUTHOR]

Subjects :: NEURODEGENERATION
NEURONS
PROTEINS
CHRONIC diseases
GENETIC models
GENE expression
BRAIN physiology
GENETICS

Full Text Access

Tools