Common variation at 10p12.31 near MLLT10 influences meningioma risk.

Authors :: Dobbins, Sara E.
Broderick, Peter
Melin, Beatrice
Feychting, Maria
Johansen, Christoffer
Andersson, Ulrika
Brännström, Thomas
Schramm, Johannes
Olver, Bianca
Lloyd, Amy
Ma, Yussanne P
Hosking, Fay J.
Lönn, Stefan
Ahlbom, Anders
Henriksson, Roger
Schoemaker, Minouk J.
Hepworth, Sarah J.
Hoffmann, Per
Mühleisen, Thomas W.
Nöthen, Markus M.
Source :: Nature Genetics; Sep2011, Vol. 43 Issue 9, p825-827, 3p, 1 Chart, 1 Graph
Publication Year :: 2011
Abstract: To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P<subscript>combined</subscript> = 1.88 × 10<superscript>?14</superscript>). This finding advances our understanding of the genetic basis of meningioma development. [ABSTRACT FROM AUTHOR]