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Mood and cognition in leucine-rich repeat kinase 2 G2019S Parkinson's disease.

Authors :
Shanker, Vicki
Groves, Mark
Heiman, Gary
Palmese, Christina
Saunders-Pullman, Rachel
Ozelius, Laurie
Raymond, Deborah
Bressman, Susan
Source :
Movement Disorders; Aug2011, Vol. 26 Issue 10, p1875-1880, 6p
Publication Year :
2011

Abstract

The behavioral and cognitive features of the leucine-rich repeat kinase G2019S mutation in Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore, we sought to more systematically characterize these features using a semistructured psychiatric interview and neuropsychological testing. Twenty-one Ashkenazi Jewish patients having the leucine-rich repeat kinase G2019S mutation were compared with age- and sex-matched Ashkenazi Jewish patients with Parkinson's disease without mutations. Although overall rates of affective disorders were not greater in mutation carriers, the carriers exhibited a 6-fold increased risk of premorbid affective disorders (odds ratio, 6.0; P = .10), as determined by the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV. Of interest, we identified 2 leucine-rich repeat kinase carriers with bipolar disorder; no mutation-negative subjects had this diagnosis. Performance on the Hopkins Verbal Learning Test-Revised, Judgment of Line Orientation, and Frontal Assessment Battery was consistent with previous reports and did not differ between groups. Study findings suggest a possible association between premorbid mood disorders and leucine-rich repeat kinase Parkinson's disease, warranting further evaluation. © 2011 Movement Disorder Society [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08853185
Volume :
26
Issue :
10
Database :
Complementary Index
Journal :
Movement Disorders
Publication Type :
Academic Journal
Accession number :
65035071
Full Text :
https://doi.org/10.1002/mds.23746