Back to Search
Start Over
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice.
- Source :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Feb2011, Vol. 66A Issue 2, p191-201, 11p, 3 Charts, 7 Graphs
- Publication Year :
- 2011
-
Abstract
- Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin’s effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging. [ABSTRACT FROM PUBLISHER]
- Subjects :
- MICE
LONGEVITY
RAPAMYCIN
AGING prevention
MORTALITY
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 66A
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 64855138
- Full Text :
- https://doi.org/10.1093/gerona/glq178