Alkylation of 3-aminoisocarbostyryl derivatives.

The alkylation of derivatives of 3-aminoisoquinolin-1(2H)-one in the presence of NaH may proceed in three directions: 1) at the carbonyl group oxygen atom, 2) at the nitrogen atom N-2, and 3) at the 3-amino group. The reaction of equivalent amounts of the reagents gives predominantly products of substitution at the 3-amino group. Repeated alkylation proceeds at the lactam fragment to give a mixture of O-alkyl and N-alkyl derivatives. Acylation of 3-dialkylamino- and 3-alkylanilinoisoquinolin- 1(2H)-ones in the presence of NaH gave derivatives of 3-amino-1-isoquinolinyl 4-ethoxybenzoate. [ABSTRACT FROM AUTHOR]