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Impact of pH on the antifungal susceptibility of vaginal Candida albicans
- Source :
- International Journal of Gynecology & Obstetrics; Sep2011, Vol. 114 Issue 3, p278-280, 3p
- Publication Year :
- 2011
-
Abstract
- <bold>Objective: </bold>To investigate the antifungal susceptibility at pH 7.0 and pH 4.0 of 5 antifungal agents against Candida albicans isolated from patients with vulvovaginal candidiasis.<bold>Methods: </bold>Antifungal susceptibility testing at pH 7.0 and pH 4.0 was performed using the broth microdilution method (CLSI, document M27-A2).<bold>Results: </bold>The minimal inhibitory concentrations (MICs) of miconazole, clotrimazole, fluconazole, and nystatin against C. albicans at pH 4.0 were significantly higher than those at pH 7.0 (0.25 vs 0.03 μg/mL, 0.50 vs 0.03 μg/mL, 0.50 vs 0.25 μg/mL, and 32 vs 2 μg/mL, respectively; P<0.001), whereas the MIC of itraconazole at pH 4.0 was lower than that at pH 7.0 (0.030 vs 0.125 μg/mL; P<0.001). The susceptibility rate of C. albicans to itraconazole at pH 4.0 was significantly higher than at pH 7.0 (95.0% vs 51.7%; P<0.001). The susceptibility rate to itraconazole at pH 7.0 was significantly lower than the susceptibility rate to fluconazole (51.7% vs 100.0%; P<0.001), whereas the susceptibility rates to the 2 drugs were similar at pH 4.0 (95.0% and 96.7%, respectively).<bold>Conclusion: </bold>Media at different pH values should be used for sensitivity tests according to the environment of C. albicans. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYSIOLOGICAL effects of hydrogen-ion concentration
CANDIDA albicans
VAGINAL diseases
ANTIFUNGAL agents
MICROBIAL sensitivity tests
GENITAL microbiology
VULVOVAGINAL candidiasis
COMPARATIVE studies
HYDROGEN-ion concentration
RESEARCH methodology
MEDICAL cooperation
RESEARCH
VAGINA
EVALUATION research
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 114
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 63983945
- Full Text :
- https://doi.org/10.1016/j.ijgo.2011.03.016