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Modifications of aminoglycoside antibiotics targeting RNA.

Authors :
Zhou, Jian
Wang, Guannan
Zhang, Li-He
Ye, Xin-Shan
Source :
Medicinal Research Reviews; May2007, Vol. 27 Issue 3, p279-316, 38p
Publication Year :
2007

Abstract

The increased awareness of the central role of RNA has led to realization that RNA, as structural and functional information accumulation, is also drug target to small molecular therapy. Aminoglycosides are a group of well-known antibiotics, which function through binding to specific sites in prokaryotic ribosomal RNA (rRNA) and affecting the fidelity of protein synthesis. Unfortunately, their clinical practice has been curtailed by toxicity and rapid increasing number of resistant strains. Therefore, it is highly desirable to design new modified aminoglycosides that will overcome the undesirable properties of natural occurring aminoglycosides. On the other hand, aminoglycosides as potential antiviral (HIV) agents were also reported. Herein, we survey the current efforts to develop new aminoglycoside derivatives with modification and reconstruction on each sugar ring and review the latest advances in structure-activity relationships (SAR). © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 3, 279-316, 2007 [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01986325
Volume :
27
Issue :
3
Database :
Complementary Index
Journal :
Medicinal Research Reviews
Publication Type :
Academic Journal
Accession number :
63622250
Full Text :
https://doi.org/10.1002/med.20085