2′,3′-Dide­hydro-3′-deoxy­thymidine N-methyl-2-pyrrolidone solvate (D4T·NMPO).

The title compound, 1-(2′,3′-di­deoxy-β- d- glycero-pent-2-eno­furan­osyl)­thymine 1-methyl-2-pyrrolidone solvate, C₁₀H₁₂N₂O₄·­C₅H₉NO, is an NMPO solvate of the anti-AIDS agent D4T. In its crystal structure, both the pyrimidine and the furan­ose rings are planar and approximately perpendicular [82.1 (4)°]. The value of the torsion angle defining the orientation of the thymine with respect to the joined furane, χ = −100.8 (4)°, and that of the torsion angle giving the orientation of the hydroxyl group linked to the furane ring, γ = 52.9 (5)°, show that the gly­cosyl­ic link adopts the so-called high- anti conformation and the 5′-hydroxyl group is in the + sc position. The NMPO solvate is linked to the nucleoside through a fairly strong hydrogen bond. [ABSTRACT FROM AUTHOR]