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Mitochondrial DNA protects against salt stress-induced cytochrome c-mediated apoptosis in yeast
- Source :
- FEBS Letters; Aug2011, Vol. 585 Issue 15, p2507-2512, 6p
- Publication Year :
- 2011
-
Abstract
- Abstract: Here we report that budding yeast mitochondrial DNA protects against salt stress-induced apoptosis. Yeast cells lacking mitochondrial DNA (ρ<superscript>0</superscript>) are hypersensitive to salt stress-induced apoptosis, which is mediated by mitochondrial cytochrome c release. In addition, cytochrome c expression is downregulated upon salt stress, suggesting a transcriptionally regulated, homeostatic protection mechanism. The repression of cytochrome c transcription is mediated by transcription factor Mig1. Consistently, deletion of MIG1 induces cytochrome C transcription and yields ρ<superscript>0</superscript> cells that are more sensitive to salt stress. In summary, deletion of mitochondrial function leads to salt stress-induced transcriptional deregulation of cytochrome C, causing apoptosis in yeast. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 585
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 63568052
- Full Text :
- https://doi.org/10.1016/j.febslet.2011.06.034