TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity.

The article discusses the findings of a study which determined the effect of TRPA1 protein in detecting mechanical stimuli in pain sensing neurons. The experiment noted the presence of TRPA1 transcript, protein, and functional expression in smaller-diameter neurons, and the recording of mechanically activated currents termed intermediately (IAMC), rapidly (RAMC), and slowly (SAMC). The study was able to demonstrate the contribution of TRPA1 to normal mechanosensation for a set of dorsal root ganglion (DRG) neurons.