Development of a poloxamer analogs/bioadhesive polymers-based in situ gelling ophthalmic delivery system for tiopronin.

The article presents a study that developed a poloxamer analogs/bioadhesive polymers-based in situ gelling ophthalmic delivery system aiming at enhancing bioavailability and anticataract effect. Also examined was the effect of poloxamer 407 (P407), poloxamer 188 (P188), carbopol 934P (C934), and sodium hyaluronate (NaHA) concentration on the gelation temperature (GT). Results showed that in vitro drug release from in situ gel was controlled by gel dissolution and followed zero-order kinetics.