A panel of p16.

Authors :: Hoevenaars, Brigiet M.
van der Avoort, Irene A.M.
de Wilde, Peter C.M.
Massuger, Leon F.A.G.
Melchers, Willem J.G.
de Hullu, Joanne A.
Bulten, Johan
Source :: International Journal of Cancer; Dec2008, Vol. 123 Issue 12, p2767-2773, 7p
Publication Year :: 2008
Abstract: Two pathways leading to vulvar squamous cell carcinoma (SCC) exist. The expression of proliferation- and cell-cycle-related biomarkers and the presence of high-risk (hr) HPV might be helpful to distinguish the premalignancies in both pathways. Seventy-five differentiated vulvar intra-epithelial neoplasia (VIN)-lesions with adjacent SCC and 45 usual VIN-lesions (32 solitary and 13 with adjacent SCC) were selected, and tested for hr-HPV DNA, using a broad-spectrum HPV detection/genotyping assay (SPF [ABSTRACT FROM AUTHOR]