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Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice.

Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice.

Authors :
Zaccone, Paola
Burton, Oliver
Miller, Nigel
Jones, Frances M.
Dunne, David W.
Cooke, Anne
Source :
European Journal of Immunology; Apr2009, Vol. 39 Issue 4, p1098-1107, 10p
Publication Year :
2009

Abstract

Schistosoma mansoni soluble egg antigens (SEA) profoundly regulate the infected host's immune system. We previously showed that SEA prevents type 1 diabetes in NOD mice and that splenocytes from SEA-treated mice have reduced ability to transfer diabetes to NOD.scid recipients. To further characterize the mechanism of diabetes prevention we examined the cell types involved and showed that CD25 T-cell depletion of splenocytes from SEA-treated donors restored their ability to transfer diabetes. Furthermore, SEA treatment increased the number and proportional representation of Foxp3 T cells in the pancreas of NOD mice. We have used in vitro systems to analyze the effect of SEA on the development of NOD Foxp3 T cells. We find that SEA can induce Foxp3 expression in naïve T cells in a TGF-β-dependent manner. Foxp3 induction requires the presence of DC, which we also show are modified by SEA to upregulate C-type lectins, IL-10 and IL-2. Our studies show that SEA can have a direct effect on CD4 T cells increasing expression of TGF-β, integrin β8 and galectins. These effects of SEA on DC and T cells may act in synergy to induce Foxp3 Treg in the NOD mouse. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00142980
Volume :
39
Issue :
4
Database :
Complementary Index
Journal :
European Journal of Immunology
Publication Type :
Academic Journal
Accession number :
61988090
Full Text :
https://doi.org/10.1002/eji.200838871