Methylprednisolone Applied Directly to the Round Window Reduces Dizziness after Cochlear Implantation: A Randomized Clinical Trial.

This prospective, double-blind controlled, randomized clinical trial of 43 adults showed that topical methylprednisolone applied to the round window during cochlear implantation was effective in protecting inner ear function. Postoperative vestibular disturbance was significantly lower in the steroid group (5%) than the control group (29%). Electrode impedances from the middle portion of the electrode array (electrodes 10-13) were significantly reduced in steroid-treated recipients compared to controls. Hearing and vestibular function analyses were under-powered to detect any drug changes due to limited participant data. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]