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Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir.
- Source :
- British Journal of Clinical Pharmacology; Aug2000, Vol. 50 Issue 2, p99, 9p
- Publication Year :
- 2000
-
Abstract
- Investigates the effect of the antiretroviral protease inhibitors saquinovir and ritonavir on the pharmacokinetic properties and tolerability of sildenafil. Effect of sildenafil on the steady-state pharmacokinetics of saquinovir and ritonavir; Indication that both saquinovir and ritonavir modify the pharmacokinetics of sildenafil presumably through inhibition of cytochrome P450 3A4.
- Subjects :
- PROTEASE inhibitors
SILDENAFIL
PHARMACOKINETICS
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 50
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- British Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6060871
- Full Text :
- https://doi.org/10.1046/j.1365-2125.2000.00245.x