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Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.
- Source :
- Endocrine (1355008X); Jun2011, Vol. 39 Issue 3, p229-234, 6p, 5 Graphs
- Publication Year :
- 2011
-
Abstract
- Glucagon-like peptide-1 (GLP-1) is secreted from the L cell of the gut in response to oral nutrient delivery. To determine if endogenously released GLP-1 contributes to the incretin effect and postprandial glucose regulation, conscious dogs ( n = 8) underwent an acclimation period ( t = −60 to −20 min), followed by a basal sampling period ( t = −20 to 0 min) and an experimental period ( t = 0-320 min). At the beginning of the experimental period, t = 0 min, a peripheral infusion of either saline or GLP-1 receptor (GLP-1R) antagonist, exendin (9-39) (Ex-9, 500 pmol/kg/min), was started. At t = 30 min, animals consumed a liquid mixed meal, spiked with acetaminophen. All animals were studied twice (± Ex-9) in random fashion, and the experiments were separated by a 1-2-week washout period. Antagonism of the GLP-1R did not have an effect, as indicated by repeated-measures MANOVA analysis of the Δ AUC from t = 45-320 min of arterial plasma glucose, GLP-1, insulin, glucagon, and acetaminophen levels. Therefore, endogenous GLP-1 is not sufficient to alter postprandial glucose regulation in the dog. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1355008X
- Volume :
- 39
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Endocrine (1355008X)
- Publication Type :
- Academic Journal
- Accession number :
- 60465746
- Full Text :
- https://doi.org/10.1007/s12020-011-9441-x