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Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in HO-induced PC12 cells.
- Source :
- Molecular Biology Reports; Jun2011, Vol. 38 Issue 5, p3561-3567, 7p, 1 Black and White Photograph, 2 Diagrams, 4 Graphs
- Publication Year :
- 2011
-
Abstract
- In this study, the effect of aucubin on HO-induced apoptosis was studied by using a rat pheochromocytoma (PC12) cell line. We have analyzed the apoptosis of HO-induced PC12 cells, HO-induced apoptosis appeared to correlate with lower Bcl-2 expression, higher Bax expression and sequential activation of caspase-3 leading to cleavage of poly-ADP-ribose polymerase (PARP). Aucubin not only inhibited lower Bcl-2 expression, high Bax expression, but also modulated caspase-3 activation, PARP cleavage, and eventually protected against HO-induced apoptosis. These results indicated that aucubin can obstruct HO-induced apoptosis by regulating of the expression of Bcl-2 and Bax, as well as suppression of caspases cascade activation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03014851
- Volume :
- 38
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Molecular Biology Reports
- Publication Type :
- Academic Journal
- Accession number :
- 60278532
- Full Text :
- https://doi.org/10.1007/s11033-010-0466-7