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Parenteral insulin suppresses T cell proliferation to islet antigens.

Authors :
Greenbaum, Carla J.
McCulloch-Olson, Marli
Chiu, Harvey K.
Palmer, Jerry P.
Brooks-Worrell, Barbara
Source :
Pediatric Diabetes; May2011, Vol. 12 Issue 3pt1, p150-155, 6p, 1 Chart, 1 Graph
Publication Year :
2011

Abstract

Greenbaum CJ, McCulloch-Olson M, Chiu HK, Palmer JP, Brooks-Worrell B. Parenteral insulin suppresses T cell proliferation to islet antigens. The diabetes prevention trial-type 1 (DPT-1) tested whether a combination of SQ and IV insulin therapy would delay the onset of disease in individuals at high risk of progression. We investigated whether this regimen altered T cell responses to human islet proteins using cellular immunoblotting. Among the 10 treated and 7 control subjects studied, we found that there was a significant effect of treatment on cellular immunoblotting responses. We conclude that parenteral insulin may suppress proliferation to islet antigens in individuals at risk for diabetes, but this effect may be transient. Further study is needed to determine whether a therapy that results in sustained suppression of T cell proliferation could yield a measurable clinical benefit. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1399543X
Volume :
12
Issue :
3pt1
Database :
Complementary Index
Journal :
Pediatric Diabetes
Publication Type :
Academic Journal
Accession number :
60153762
Full Text :
https://doi.org/10.1111/j.1399-5448.2010.00674.x