Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR.

The article correct the results in a study that previously appeared in the 2007 issue of the magazine regarding the physical interaction of the enzyme Transketolase A (TktA) with the MarR, finding that it depresses the Escherichia coli marRAB multiple antibiotic resistance operon. It cites that further laboratory work failed to confirm the interaction of the TktA gene with the MarR. It indicates that the original conclusions may have resulted from an unexplained variability of LacZ activity.