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High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients.
- Source :
- British Journal of Cancer; 4/12/2011, Vol. 104 Issue 8, p1334-1341, 8p, 1 Color Photograph, 2 Diagrams, 3 Charts
- Publication Year :
- 2011
-
Abstract
- <bold>Background: </bold>High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention.<bold>Methods: </bold>High-risk human papillomavirus DNA was investigated in 140 non-melanoma skin lesions from 54 immunocompetent patients and 33 immunosuppressed renal allograft recipients. Expression of p16(INK4a), a marker for HR-HPV oncogene expression in the uterine cervix, and of p53 and pRB was evaluated immunohistochemically.<bold>Results: </bold>The highest prevalence of HR-HPV was found in squamous cell cancer (SCC) (46.2% (6 out of 13) in immunosuppressed and 23.5% (4 out of 17) in immunocompetent patients). High-risk human papillomavirus positivity was accompanied by diffuse p16(INK4a) expression in most SCC (P<0.001) and basal cell cancers (P=0.02), while almost all SCC in situ were p16(INK4a) positive irrespective of HR-HPV presence (P=0.66). Diffuse p16(INK4a) expression was associated with lack of pRB expression (P=0.001). p53 was strongly expressed in 40.0% (56 out of 140) of the lesions irrespective of HR-HPV presence.<bold>Conclusion: </bold>High-risk human papillomavirus can be detected in lesions of keratinised squamous epithelia. The association of HR-HPV with diffuse p16(INK4a) expression might indicate HR-HPV oncogene expression in a proportion of lesions. Overexpression of p53 suggests p53 pathway alterations in HR-HPV-positive and -negative lesions. [ABSTRACT FROM AUTHOR]
- Subjects :
- PAPILLOMAVIRUSES
RISK factors of skin cancer
KIDNEY transplant patients
PRECANCEROUS conditions
IMMUNOSUPPRESSION
ONCOGENES
MELANOMA
PATIENTS
DNA analysis
COMMUNICABLE disease epidemiology
SKIN diseases
RESEARCH
VERTEBRATES
IMMUNOCOMPETENCE
HOMOGRAFTS
DNA
COMMUNICABLE diseases
IMMUNOCOMPROMISED patients
RESEARCH methodology
KIDNEY transplantation
MEDICAL cooperation
EVALUATION research
SKIN tumors
COMPARATIVE studies
VIRUS diseases
PAPILLOMAVIRUS diseases
DISEASE prevalence
SQUAMOUS cell carcinoma
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 104
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 59963046
- Full Text :
- https://doi.org/10.1038/bjc.2011.95