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Association of Sequence Variants on Chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) With Glioma Susceptibility in a Chinese Population.
- Source :
- American Journal of Epidemiology; Apr2011, Vol. 173 Issue 8, p915-922, 8p
- Publication Year :
- 2011
-
Abstract
- Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n = 312), in a Chinese population (2004–2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10−6)), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10−6)), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10−4)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10−7); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10−3); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10−4 and P = 2.84 × 10−4, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations. [ABSTRACT FROM PUBLISHER]
- Subjects :
- GLIOMAS
CHI-squared test
CHROMOSOMES
COMPARATIVE studies
CONFIDENCE intervals
STATISTICAL correlation
DISEASE susceptibility
EPIDEMIOLOGY
FISHER exact test
GENES
GENETIC polymorphisms
GENETIC techniques
NUCLEOTIDES
PROBABILITY theory
RESEARCH funding
LOGISTIC regression analysis
DATA analysis
CONTROL groups
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 173
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 59962292
- Full Text :
- https://doi.org/10.1093/aje/kwq457