Mutation rates in the dystrophin gene: A hotspot of mutation at a CpG dinucleotide.

The article discusses a study on the mutation rates in the dystrophin gene in Duchenne muscular dystrophy (DMD) patients. It defines DMD as an X-linked recessive lethal disorder that mainly affects male births. In the study, the detection of virtually all mutations-SSCP (DOVAM-S) was utilized for mutation scanning. Duplication scanning was also conducted through the use of multiplex amplifiable probe hybridization (MAPH).