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Common SNPs in Myelin Transcription Factor 1-Like (MYT1L): Association with Major Depressive Disorder in the Chinese Han Population.
- Source :
- PLoS ONE; 2010, Vol. 5 Issue 10, p1-5, 5p
- Publication Year :
- 2010
-
Abstract
- Background: Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD. Methods: In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin. Results: Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007). Conclusion: Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 59308679
- Full Text :
- https://doi.org/10.1371/journal.pone.0013662