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Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants.
- Source :
- Journal of Infectious Diseases; 2/15/2011, Vol. 203 Issue 4, p556-560, 5p, 1 Chart, 1 Graph
- Publication Year :
- 2011
-
Abstract
- Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxymeasure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 203
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 58040203
- Full Text :
- https://doi.org/10.1093/infdis/jiq079