Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y Neuroblastoma cells.

Authors :: DESLAURIERS, JESSICA
LEFRANÇOIS, Marilou
LAROUCHE, ANNIE
SARRET, PHILIPPE
GRIGNON, SYLVAIN
Source :: Synapse; Apr2011, Vol. 65 Issue 4, p321-331, 11p, 1 Color Photograph, 6 Graphs
Publication Year :: 2011
Abstract: The article presents a study which investigated the effects of antipsychotic (AP) drugs and α-lipoic acid on dopamine D2 receptors (DRD2) in human SH-SY5Y neuroblastoma cells. The AP drugs haloperidol and amisulpride were used. Results show that haloperidol induces DRD2 upregulation, which can be inhibited by α-lipoic acid.

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