Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing.

The article presents a study on the effect of small interfering RNA (siRNA) nuclease stability on in vitro and in vivo kinetics of siRNA-mediated gene slicing. The study revealed that three different siRNAs target three different regions on the luciferase mRNA transcript including the siGL3, siLuc2 and siLuc1. The study concluded that the duration of luciferase knockdown in vitro was not affected by the siRNA nuclease stability following electroporation.