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Are Lipid Ratios Less Susceptible to Change With Systemic Inflammation Than Individual Lipid Components in Patients With Rheumatoid Arthritis?
- Source :
- Angiology; 2/1/2011, Vol. 62 Issue 2, p167-175, 9p
- Publication Year :
- 2011
-
Abstract
- Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P ≤ .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA. [ABSTRACT FROM PUBLISHER]
- Subjects :
- STATINS (Cardiovascular agents)
ANALYSIS of variance
CARDIOVASCULAR diseases risk factors
COMPUTER software
CONFIDENCE intervals
STATISTICAL correlation
EPIDEMIOLOGY
HYPERLIPIDEMIA
INFLAMMATION
LIPIDS
LONGITUDINAL method
MULTIVARIATE analysis
REGRESSION analysis
RESEARCH funding
RHEUMATOID arthritis
STATISTICS
LOGISTIC regression analysis
DATA analysis
MULTIPLE regression analysis
CROSS-sectional method
RETROSPECTIVE studies
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 62
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 57331360
- Full Text :
- https://doi.org/10.1177/0003319710373749