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Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q.
- Source :
- Leukemia (08876924); Jan2011, Vol. 25 Issue 1, p110-120, 11p, 5 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- This cooperative study assessed prognostic factors for overall survival (OS) and risk of transformation to acute myeloid leukemia (AML) in 541 patients with de novo myelodysplastic syndrome (MDS) and deletion 5q. Additional chromosomal abnormalities were strongly related to different patients' characteristics. In multivariate analysis, the most important predictors of both OS and AML transformation risk were number of chromosomal abnormalities (P<0.001 for both outcomes), platelet count (P<0.001 and P=0.001, respectively) and proportion of bone marrow blasts (P<0.001 and P=0.016, respectively). The number of chromosomal abnormalities defined three risk categories for AML transformation (del(5q), del(5q)+1 and del(5q)+ ≥ 2 abnormalities) and two for OS (one group: del(5q) and del(5q)+1; and del(5q)+ ≥ 2 abnormalities, as the other one); with a median survival time of 58.0 and 6.8 months, respectively. Platelet count (P=0.001) and age (P=0.034) predicted OS in patients with '5q-syndrome'. This study demonstrates the importance of additional chromosomal abnormalities in MDS patients with deletion 5q, challenges the current '5q-syndrome' definition and constitutes a useful reference series to properly analyze the results of clinical trials in these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHROMOSOME abnormalities
ACUTE myeloid leukemia
MYELODYSPLASTIC syndromes
HUMAN cytogenetics
DYSPLASIA
CHROMOSOMES
COMPARATIVE studies
KARYOTYPES
RESEARCH methodology
MEDICAL cooperation
GENETIC mutation
PROGNOSIS
RESEARCH
RESEARCH funding
EVALUATION research
RETROSPECTIVE studies
MACROCYTIC anemia
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Leukemia (08876924)
- Publication Type :
- Academic Journal
- Accession number :
- 57323971
- Full Text :
- https://doi.org/10.1038/leu.2010.231