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Association of Age and Comorbidity with Physical Function in HIV-Infected and Uninfected Patients: Results from the Veterans Aging Cohort Study.
- Source :
- AIDS Patient Care & STDs; Jan2011, Vol. 25 Issue 1, p13-20, 8p, 4 Charts, 2 Graphs
- Publication Year :
- 2011
-
Abstract
- HIV clinical care now involves prevention and treatment of age-associated comorbidity. Although physical function is an established correlate to comorbidity in older adults without HIV infection, its role in aging of HIV-infected adults is not well understood. To investigate this question we conducted cross-sectional analyses including linear regression models of physical function in 3227 HIV-infected and 3240 uninfected patients enrolled 2002-2006 in the Veterans Aging Cohort Study-8-site (VACS-8). Baseline self-reported physical function correlated with the Short Form-12 physical subscale (ρ = 0.74, p < 0.001), and predicted survival. Across the age groups decline in physical function per year was greater in HIV-infected patients (β<subscript>coef</subscript> −0.25, p < 0.001) compared to uninfected patients (β<subscript>coef</subscript> −0.08, p = 0.03). This difference, although statistically significant ( p < 0.01), was small. Function in the average 50-year old HIV-infected subject was equivalent to the average 51.5-year-old uninfected subject. History of cardiovascular disease was a significant predictor of poor function, but the effect was similar across groups. Chronic pulmonary disease had a differential effect on function by HIV status (Δβ<subscript>coef</subscript> −3.5, p = 0.03). A 50-year-old HIV-infected subject with chronic pulmonary disease had the equivalent level of function as a 68.1-year-old uninfected subject with chronic pulmonary disease. We conclude that age-associated comorbidity affects physical function in HIV-infected patients, and may modify the effect of aging. Longitudinal research with markers of disease severity is needed to investigate loss of physical function with aging, and to develop age-specific HIV care guidelines. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGE distribution
ANALYSIS of variance
CARDIOVASCULAR diseases risk factors
COMPARATIVE studies
STATISTICAL correlation
HIV-positive persons
LIFE skills
LONGITUDINAL method
OBSTRUCTIVE lung diseases
VETERANS
QUESTIONNAIRES
SELF-evaluation
COMORBIDITY
MULTIPLE regression analysis
SECONDARY analysis
CONTROL groups
CROSS-sectional method
PROPORTIONAL hazards models
Subjects
Details
- Language :
- English
- ISSN :
- 10872914
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- AIDS Patient Care & STDs
- Publication Type :
- Academic Journal
- Accession number :
- 57217972
- Full Text :
- https://doi.org/10.1089/apc.2010.0242