Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.

Authors :: Yazawa, Katsukiyo
Mikami, Yuzuru
Maeda, Akio
Morisaki, Naoko
Iwasaki, Shigeo
Yazawa, K
Mikami, Y
Maeda, A
Morisaki, N
Iwasaki, S
Source :: Journal of Antimicrobial Chemotherapy (JAC); Jun1994, Vol. 33 Issue 6, p1127-1135, 9p
Publication Year :: 1994
Abstract: Rifampicin was inactivated by Nocardia otitidiscaviarum to yield two products designated RIP-3 and RIP-4. The full structures of RIP-3 and RIP-4 were determined to be 21-(O-phosphoryl) rifampicin and 3-formyl-21-(O-phosphoryl) rifamycin SV, respectively, but neither product had any antimicrobial activity. [ABSTRACT FROM AUTHOR]

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