Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid from to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro.

Mucoid strains of isolated from the sputa of patients with cystic fibrosis or through selection with phage were more resistant to carbenicillin, flucloxacillin and tobramycin and more sensitive to tetracycline than related non-mucoid strains. The observations led to the development of a technique for the isolation of mucoid variants based on enhanced resistance to carbenicillin. Mucoid variants were isolated from various strains of and the exopolysaccharide found to be similar to that obtained from mucoid isolated from patients with cystic fibrosis. [ABSTRACT FROM PUBLISHER]