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In-utero transplantation of fetal liver stem cells into human fetuses.
- Source :
- Human Reproduction; Jan1992, Vol. 7 Issue 1, p44-48, 5p
- Publication Year :
- 1992
-
Abstract
- Three human fetuses were treated by transplantation of human fetal liver stem cells. Two of them had severe immunodeficiency disease and the third had thalassaemia major. All three in-utero transplants were followed by engraftment. No adverse effect was seen. The three patients have now been born: the first is very healthy thanks to the reconstitution of cell-mediated immunity associated with this transplant, and he lives normally at home; the other two, who were treated more recently, have not yet shown a complete effect. The feasibility and efficacy of this procedure, used for the first time in humans, has therefore been demonstrated: during early fetal development, foreign cells engraft readily and may result in significant improvement of a large variety of inherited diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02681161
- Volume :
- 7
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Human Reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 55965080