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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Authors :
Weggen, Sascha
Eriksen, Jason L.
Das, Pritam
Sagi, Sarah A.
Rong Wang
Pietrzik, Claus U.
Findlay, Kirk A.
Smith, Tawnya E.
Murphy, Michael P.
Butler, Thomas
Kang, David E.
Marquez-Sterling, Numa
Golde, Todd E.
Koo, Edward H.
Source :
Nature; 11/8/2001, Vol. 414 Issue 6860, p212, 5p, 2 Black and White Photographs, 1 Chart, 10 Graphs
Publication Year :
2001

Abstract

Reports the beneficial effects of nonsteroidal anti-inflammatory drugs (NSAID). Reduction of the occurrence of Alzheimer's disease; Reaction of NSAID to Abeta42 peptide; Impact of the drugs to the amyloid pathology in the brain.

Details

Language :
English
ISSN :
00280836
Volume :
414
Issue :
6860
Database :
Complementary Index
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
5591985
Full Text :
https://doi.org/10.1038/35102591