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Arterial Stiffness and Gait Speed in Older Adults With and Without Peripheral Arterial Disease.
- Source :
- American Journal of Hypertension; Jan2011, Vol. 24 Issue 1, p90-95, 6p
- Publication Year :
- 2011
-
Abstract
- BackgroundCentral arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease.MethodsWe analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age ± s.d. 73.6 ± 2.9 years, 48% men, 39% black).ResultsIn mixed-effects models adjusted for demographics, each s.d. (396 cm/s) higher PWV was associated with 0.015 (s.e. 0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P < 0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with 0.028 (s.e. 0.010) m/s slower gait speed at baseline and throughout the study period (P < 0.01).ConclusionsThese findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.American Journal of Hypertension (2011). doi:10.1038/ajh.2010.193 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08957061
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 55835706
- Full Text :
- https://doi.org/10.1038/ajh.2010.193