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Evidence That Prenatal Programming of Hypertension by Dietary Protein Deprivation Is Mediated by Fetal Glucocorticoid Exposure.
- Source :
- American Journal of Hypertension; Jan2011, Vol. 24 Issue 1, p96-101, 6p
- Publication Year :
- 2011
-
Abstract
- BackgroundPrenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension when the offspring are studied as adults.MethodsTo determine whether prenatal dietary protein deprivation results in a reduction in nephron number and hypertension in offspring by exposure to maternal glucocorticoids, we administered metyrapone to rats fed either a 6% or 20% protein diet to inhibit glucocorticoid production and compared the offspring to rats that were the product of mothers fed either a 6% or 20% protein diet during the last half of pregnancy.ResultsMale offspring from the 6% group had elevated systolic blood pressure (149 ± 2 vs. 130 ± 5 mm Hg, P < 0.05) and a reduction in glomeruli compared to the 20% group (22,111 ± 627 vs. 29,666 ± 654 glomeruli/kidney, P < 0.001). Maternal metyrapone administration did not affect the blood pressure in the 20% group but ameliorated the increase in blood pressure in the 6% male group to values comparable to the 20% control group (138 ± 6 vs. 130 ± 5 mm Hg). Male offspring of the 6% group that received metyrapone had an increase in the number of glomeruli compared to the vehicle-treated 6% group (26,780 ± 377 vs. 22,111 ± 627 glomeruli/kidney, P < 0.001), but less glomeruli compared to the 20% protein control group (26,780 ± 377 vs. 29,666 ± 654 glomeruli/kidney, P = 0.01).ConclusionsThe reduction in nephron number and hypertension induced by maternal protein deprivation in male offspring is ameliorated by inhibition of glucocorticoid production.American Journal of Hypertension (2011). doi:10.1038/ajh.2010.177 [ABSTRACT FROM AUTHOR]
- Subjects :
- DEXAMETHASONE
HYPERTENSION
PRENATAL care
KIDNEY tubules
GLUCOCORTICOIDS
Subjects
Details
- Language :
- English
- ISSN :
- 08957061
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 55835701
- Full Text :
- https://doi.org/10.1038/ajh.2010.177