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Tanreqing Injection Combined with Conventional Western Medicine for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review.
- Source :
- Journal of Alternative & Complementary Medicine; Dec2010, Vol. 16 Issue 12, p1309-1319, 11p, 6 Diagrams, 2 Charts, 1 Graph
- Publication Year :
- 2010
-
Abstract
- Objective: In China, most patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) are usually treated with Tanreqing injection plus conventional Western medicine. However, the value of its use remains uncertain. The objective of this systematic review is to compare the efficacy of Tanreqing injection plus conventional Western medicine with that of conventional Western medicine alone (therapy A versus therapy B, respectively) in the management of acute exacerbations of COPD. Methods: Literature retrieval was conducted using the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE,<superscript>®</superscript> EMBASE, Chinese Biomedical Database (CBM), and other electronically available databases from respective inception to August 2009. In addition, manual search of some traditional Chinese journals was performed to identify potential studies. Review authors independently extracted the trial data and assessed the quality of each trial. The following outcomes were evaluated: (1) forced expiratory volume in 1 second as a percentage of the predicted value; (2) arterial partial pressure of oxygen (P o<subscript>2</subscript>); (3) arterial partial pressure of carbon dioxide (P co<subscript>2</subscript>); (4) length of hospital stay; (5) marked efficacy rate; (6) interleukin-8; and (7) adverse events. Results: Based on the search strategy, 14 trials involving 954 patients were finally included. Our results showed that compared with therapy B, therapy A improved P o<subscript>2</subscript>, clinical efficacy, and lung function, reduced P co<subscript>2</subscript>, shortened the length of hospital stay, and was thus more therapeutically beneficial. No serious adverse events were reported. Conclusions: Within the limitations of this systematic review, we can conclude that compared with therapy B, therapy A may provide more benefits for patients with acute exacerbations of COPD. Further large-scale high-quality trials are warranted. [ABSTRACT FROM AUTHOR]
- Subjects :
- OBSTRUCTIVE lung disease treatment
THERAPEUTIC use of plant extracts
RESEARCH methodology evaluation
MEDICINAL plants
ALTERNATIVE medicine
ANALYSIS of variance
ARTERIES
BLOOD pressure
CHI-squared test
COMPUTER software
CONFIDENCE intervals
EXPERIMENTAL design
LENGTH of stay in hospitals
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
INTERLEUKINS
INTRAVENOUS therapy
MEDICINE
CHINESE medicine
MEDLINE
META-analysis
HEALTH outcome assessment
STATISTICAL hypothesis testing
EVIDENCE-based medicine
PLANT extracts
PROFESSIONAL practice
DATA analysis
EFFECT sizes (Statistics)
RELATIVE medical risk
TREATMENT effectiveness
RESEARCH bias
VITAL capacity (Respiration)
PUBLICATION bias
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 10755535
- Volume :
- 16
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Alternative & Complementary Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 55644390
- Full Text :
- https://doi.org/10.1089/acm.2009.0686