Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis.

The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not known. The presence of prothrombin 19911 A>G was investigated in a case-control study of 107 patients with cerebral thrombosis and factor V Leiden ( n = 25), prothrombin 20210 GA ( n = 47), without known thrombophilia ( n = 35) and 842 healthy individuals with the corresponding coagulation profile. Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6-4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6-2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5-3.1). Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA. [ABSTRACT FROM AUTHOR]