Back to Search
Start Over
Citalopram versus other antidepressants for late-life depression: a systematic review and meta-analysis.
- Source :
- International Journal of Geriatric Psychiatry; Dec2010, Vol. 25 Issue 12, p1296-1305, 10p, 1 Diagram, 5 Charts
- Publication Year :
- 2010
-
Abstract
- Objective: To determine the efficacy and tolerability of citalopram when compared to other antidepressants for late-life depression (LLD). Methods: We searched electronic databases and trial registries to identify randomized controlled trials comparing citalopram to other antidepressants for LLD. Study quality was assessed using the Cochrane collaboration risk of bias tool. We summarized the efficacy of citalopram compared to other antidepressants by examining rates of depression remission, depression response and change in depression symptom scores. Medication tolerability was assessed through trial withdrawals due adverse events and withdrawals due to any cause. We used meta-analysis to determine the odds ratios (OR) of efficacy and tolerability outcomes for citalopram compared to other antidepressants. Results: Seven studies comparing citalopram (N¼647) to other antidepressants (N¼641) for LLD were identified including four studies with tricyclic comparators and three studies with non-tricyclic comparators. Most of the studies had methodological limitations that placed them at risk for potential bias. The majority of studies reported no significant differences between citalopram and comparator medications for depression efficacy or tolerability outcomes. Meta-analysis did not find any significant differences between citalopram and other antidepressants for depression remission [OR¼0.84; 95%CI: 0.56–1.28] or for trial withdrawals due to adverse effects [OR¼0.70; 95%CI: 0.48–1.02]. Conclusions: Currently there are few studies directly comparing citalopram to other antidepressants for LLD. The small number of studies and methodological issues in many studies limit any conclusions about the relative efficacy and tolerability of citalopram compared to other antidepressants. Well designed studies comparing citalopram to other antidepressants for LLD are required. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIDEPRESSANTS
COMPUTER software
CONFIDENCE intervals
MENTAL depression
EPIDEMIOLOGY
MEDICAL databases
INFORMATION storage & retrieval systems
MEDICAL information storage & retrieval systems
MEDLINE
META-analysis
HEALTH outcome assessment
SEROTONIN uptake inhibitors
DATA analysis
SCALE items
TREATMENT effectiveness
DRUG therapy
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 08856230
- Volume :
- 25
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- International Journal of Geriatric Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 55255569
- Full Text :
- https://doi.org/10.1002/gps.2483