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Canarypox Vaccines Induce Antigen-Specific Human gammadelta T Cells Capable of Interferon-gamma Production.

Authors :
Worku, Shewangizaw
Gorse, Geoffrey J.
Belshe, Robert B.
Hoft, Daniel F.
Source :
Journal of Infectious Diseases; 9/1/2001, Vol. 184 Issue 5, p525, 8p
Publication Year :
2001

Abstract

Induction of human γδ T cells was investigated in subjects who were vaccinated with live recombinant canarypox virus expressing human immunodeficiency virus (HIV) proteins or soluble MN rgp120. Both canarypox and rgp120 induced antigen-specific lymphoproliferative and interferon (IFN)—γ responses. However, only canarypox vaccination induced increased γδ T cell responses detectable after secondary in vitro expansion (P < .02). These enhanced γδ T cell responses were specific for canarypox but not HIV antigens. Canarypox-specific γδ T cells were predominantly Vγ9[sub +] and produced intracellular and secreted IFN-γ. γδ T cell lines generated from canarypox vaccinees responded to canarypox antigens but not to mycobacterial antigens shown previously to induce bacille Calmette-Guérin—specific γδ T cells. Furthermore, canarypox vaccinations were associated with significantly higher NK cell expansions (P = .02). Increased IFN—γ production by γδ T and NK cells could enhance the induction of protective type 1 memory immunity. Thus, stimulation of γδ T cells might be an important feature of live vaccines. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
184
Issue :
5
Database :
Complementary Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
5502607
Full Text :
https://doi.org/10.1086/322792