Potential carriers for controlled drug release based on interpolyelectrolyte complexes using Eudragit types EPO and L100-55. I. Synthesis and comparative physicochemical evaluation.

New interpolyelectrolyte complexes (IPEC) between oppositely charged types of Eudragit, EPO and L100-55, with different molar ratios were synthesized with the aim of seeking potential carriers for oral delivery systems. Elemental analysis showed that the resulting polycomplexes had different compositions, with 0.36 < Z = [EPO]/[L100] < 1.81. The structural properties of the materials assessed by IR spectroscopy and modulated-temperature differential scanning calorimetry showed that all IPEC were stabilized by a cooperative system of ionic bonds, were chemically homogeneous, and were characterized by the presence of a single glass transition temperature. These properties suggest that the polycomplexes synthesized here have potential for further study as carriers for controlled drug release in specified parts of the gastrointestinal tract. [ABSTRACT FROM AUTHOR]