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Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study.
- Source :
- Clinical Endocrinology; Dec2000, Vol. 53 Issue 6, p733-737, 5p
- Publication Year :
- 2000
-
Abstract
- We investigated the prospective relationship between thyroid status and the risk of dementia and Alzheimer's disease among a random sample of 1843 participants, aged 55 years and over, from the population-based prospective Rotterdam Study. Thyroid status was measured at baseline (1990–93), through assessment of serum antibodies to thyroid peroxidase (TPO-Abs, positive: >10 IU/ml), serum TSH levels, and when TSH was abnormal (<0·4 or >4·0 mU/l), serum thyroxin levels (T4). At baseline and at follow up, after on average 2 years, participants were screened for dementia. Diagnoses were based on international criteria. Persons with reduced TSH levels at baseline had a more than threefold increased risk of dementia (RR = 3·5, 95%CI: 1·2–10·0) and of Alzheimer's disease (RR = 3·5, 95%CI: 1·1–11·5), after adjustment for age and sex. Among persons with reduced TSH levels, T4 levels appeared to be positively related to the risk of dementia (RR per SD increase = 2·9, 95%CI: 0·7–12·2), although none of those who became demented had a T4 level above the normal range (>140 nmol/l). The risk of dementia was especially increased in subjects with low TSH who were positive for TPO-Abs (RR = 23·7, 95%CI: 4·0–140). This is the first prospective study to suggest that subclinical hyperthyroidism in the elderly increases the risk of dementia and Alzheimer's disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERTHYROIDISM
DEMENTIA
ALZHEIMER'S disease
Subjects
Details
- Language :
- English
- ISSN :
- 03000664
- Volume :
- 53
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Clinical Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 5481166
- Full Text :
- https://doi.org/10.1046/j.1365-2265.2000.01146.x