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Steady-State Pharmacokinetics of Lamivudine Once-Daily Versus Twice-Daily Dosing in Chinese HIV-Infected Patients.
- Source :
- HIV Clinical Trials; Jul/Aug2010, Vol. 11 Issue 4, p230-237, 8p, 4 Charts, 1 Graph
- Publication Year :
- 2010
-
Abstract
- Objective: The present study aimed to compare the pharmacokinetics of lamivudine in 300 mg once-daily and 150 mg twice-daily dosing regimens in HIV-infected Chinese patients. Methods: HIV-infected patients received lamivudine 300 mg once daily or 150 mg twice daily as part of a highly active antiretroviral therapy regimen. After the patients received lamivudine for at least 3 months, serial blood samples were collected for 24 hours. The samples were measured by a validated high-performance liquid chromatography (HPLC) assay. The pharmacokinetics of once-daily versus twice-daily dosing was evaluated by noncompartment models. Results: Ten patients received lamivudine 300 mg once daily and 5 patients received 150 mg twice daily. The Cmax was significantly higher in the once-daily arm than the twice-daily arm (2.23 vs 1.61 μg/mL, P <.05), whereas the Cmin was markedly lower (0.05 vs 0.12 μg/mL, P <.05). The half-lives were 3.32 hours and 2.62 hours, and AUC24 values were 11.8 μg/mL·h and 13.0 μg/mL·h in the 300 mg once-daily and 150 mg twice-daily regimens, respectively (P &nvgt;.05). Conclusion: The shorter half-life was observed first in Chinese HIV patients with once- and twice-daily regimens. The 300 mg once-daily regimen was associated with lower trough concentrations and remarkable interpatient variability. Further studies in large groups of HIV patients are needed to confirm the influence of shorter half-lives in Chinese patients on efficacy and toxicity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15284336
- Volume :
- 11
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- HIV Clinical Trials
- Publication Type :
- Academic Journal
- Accession number :
- 54604677
- Full Text :
- https://doi.org/10.1310/hct1104-230