Synthesis and physicochemical evaluation of a new carrier based on an interpolyelectrolyte complex formed by Eudragit® EPO and Carbomer 940.

The formation of interpolyelectrolyte complexes (IPEC) between Eudragit EPO (EPO) and Carbomer 940 (C940) was investigated with a view to their use in peroral controlled-release drug delivery systems. The structure of the synthesized products was investigated using FTIR spectroscopy and MT-DSC methods, which indicated that the synthesized product can be considered to be an IPEC stabilized by a cooperative system of ionic bonds. Based on results of capillary viscosimetry and elemental analysis, the IPEC prepared at pH 4.0 has a characteristic composition with a C940:EPO mole ratio of 1.75:1. [ABSTRACT FROM AUTHOR]