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Perfusion defects on real-time myocardial contrast echocardiography predict higher mortality in patients with end-stage renal disease - A 3-year follow-up.
- Source :
- Renal Failure; 2010, Vol. 32 Issue 10, p1160-1166, 7p, 4 Charts, 1 Graph
- Publication Year :
- 2010
-
Abstract
- Aim: The aim of this study was to assess the prognostic significance of myocardial contrast echocardiography (MCE) in patients with end-stage renal disease (ESRD) on a 3-year follow-up and to compare the value of MCE with demographic, clinical, and laboratory parameters. Methods: Fifty-eight ESRD patients on regular dialysis were prospectively screened for coronary artery disease (CAD) using perfusion assessment on real-time MCE. We analyzed the following end points during the 3-year follow-up: death, cardiovascular complications, and combined end point, which consisted of adverse cardiac events mentioned above. All features were compared between the two groups with and without perfusion disturbances on MCE. Results: No adverse events related to MCE administration have been observed. Twenty-seven (47%) patients with ESRD demonstrated perfusion defects on MCE. The patients with perfusion defects on MCE comparison with those without perfusion disturbances were older ( p = 0.008) and had lower ejection fraction (EF) ( p = 0.0001) and higher wall motion index (WMSI) ( p = 0.0001). After the 3-year follow-up, the incidence of death ( p = 0.00018), cardiovascular end points, revascularizations [both percutaneous coronary intervention (PCI) and coronary artery bypass grafts (CABG) p = 0.0016 and p = 0.004, respectively], and composite end point ( p = 0.0015) was significantly higher in patients with perfusion defect on MCE. Conclusions: In patients with ESRD, MCE appears to be a safe and useful tool for risk stratification. MCE facilitates decision for coronary angiography. [ABSTRACT FROM AUTHOR]
- Subjects :
- KIDNEY diseases
ECHOCARDIOGRAPHY
MORTALITY
DIALYSIS (Chemistry)
PERFUSION
Subjects
Details
- Language :
- English
- ISSN :
- 0886022X
- Volume :
- 32
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Renal Failure
- Publication Type :
- Academic Journal
- Accession number :
- 54464083
- Full Text :
- https://doi.org/10.3109/0886022X.2010.516855