Back to Search
Start Over
Novel antifungal activity of purpurin against Candida species in vitro.
- Source :
- Medical Mycology; Nov2010, Vol. 48 Issue 7, p904-911, 8p
- Publication Year :
- 2010
-
Abstract
- The antifungal activity of purpurin (1,2,4-trihydroxy-9,10-anthraquinone), a natural red anthraquinone pigment in madder root ( Rubia tinctorum L.), was evaluated by a broth microdilution assay against a total of 24 Candida isolates representing six species. The minimum inhibitory concentration (MIC) range of purpurin was 1.28-5.12 μg/ml. Mechanistic studies using the rhodamine 6G extrusion assay indicated that purpurin inhibited the energy-dependent efflux pumps of the Candida isolates in a dose-dependent manner. Furthermore, purpurin demonstrated a dose-dependent depolarization of mitochondrial membrane potential, one of the biochemical checkpoints regulating cell death in eukaryotic cells, suggesting a possible linkage between purpurin antifungal mechanism and Candida apoptosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13693786
- Volume :
- 48
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Medical Mycology
- Publication Type :
- Academic Journal
- Accession number :
- 54089017
- Full Text :
- https://doi.org/10.3109/13693781003739351