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α-Synuclein gene duplication impairs reward learning.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 9/7/2010, Vol. 107 Issue 36, p15992-15994, 3p, 1 Chart, 2 Graphs
- Publication Year :
- 2010
-
Abstract
- α-Synuclein (SNC4) plays an important rote in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkin- son disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment learning compared with noncarriers. These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEURAL transmission
PARKINSON'S disease patients
GENES
DISABILITIES
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 107
- Issue :
- 36
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 53877370
- Full Text :
- https://doi.org/10.1073/pnas.1006068107