Recurrence after Treatment for Pulmonary Multidrug-Resistant Tuberculosis.

Authors :: Becerra, Mercedes C.
Appleton, Sasha C.
Franke, Molly F.
Chalco, Katiuska
Bayona, Jaime
Murray, Megan B.
Mitnick, Carole D.
Source :: Clinical Infectious Diseases; 9/15/2010, Vol. 51 Issue 6, p709-711, 3p, 1 Graph
Publication Year :: 2010
Abstract: We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness—that all 16 episodes were caused by the original tuberculosis strain—then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve. [ABSTRACT FROM AUTHOR]