A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGNElectronic supplementary information (ESI) available: Additional figures, including binding curves, and detailed biochemical and synthetic experimental procedures. See DOI: 10.1039/c0cc00830c

Authors :: Garber, Kathleen C. A.
Wangkanont, Kittikhun
Carlson, Erin E.
Kiessling, Laura L.
Source :: Chemical Communications; 9/28/2010, Vol. 46 Issue 36, p6747-6749, 3p
Publication Year :: 2010
Abstract: Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission. [ABSTRACT FROM AUTHOR]

Subjects :: SHIKIMIC acid
HIV
HIV infection transmission
LECTINS
DENDRITIC cells
BIOCHEMISTRY

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