Interleukin-18 Polymorphism and Physical Functioning in Older People: A Replication Study and Meta-Analysis.

Authors :: Thomas, Kate
Rafiq, Sajjad
Frayling, Timothy M.
Ebrahim, Shah
Kumari, Meena
Gallacher, John
Ferrucci, Luigi
Bandinelli, Stefania
Wallace, Robert B.
Melzer, David
Martin, Richard M.
Ben-Shlomo, Yoav
Source :: Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Nov2009, Vol. 64A Issue 11, p1177-1182, 6p, 4 Charts
Publication Year :: 2009
Abstract: Background: Levels of the proinflammatory cytokine interleukin-18 (IL-18) are raised in old age and are associated with reduced physical functioning. Previous studies have indicated that the C allele of the rs5744256 polymorphism in the IL-18 gene is strongly associated with reduced circulating IL-18 levels. This variant has previously been associated with improved locomotor performance in old age, but the finding requires independent replication. [ABSTRACT FROM PUBLISHER]

Subjects :: GERIATRICS
INTERLEUKINS
WALKING
GENETIC polymorphisms
MEDICAL research
AGING

Language :: English
ISSN :: 10795006
Volume :: 64A
Issue :: 11
Database :: Complementary Index
Journal :: Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Publication Type :: Academic Journal
Accession number :: 53299266
Full Text :: https://doi.org/10.1093/gerona/glp092

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